Champions Barcelona return to action on Sunday when they welcome Alavés at the Estadi Johan Cruyff.
The log leaders will be aiming to make it nine wins in nine matches this season and maintain their 100% record.
The hosts will be hoping that upcoming forward Salma Paralluelo will take motivation from her hattrick against Argentina during the international break and score more goals for them going forward. Besides her, the hosts will also be looking up to the midfield trio of Patri Guijarro, Aitana Bonmatí and Keira Walsh for stability whilst looking up to forwards Mariona Caldentey, Asisat Oshoala and Geyse for more goals.
On the other hand, struggling Alavés would have wanted a motivating return after the break to collect maximum points to put their campaign on track and would not have preferred Barcelona as their opponents.
The teams have met twice and Barcelona won both of them scoring 15 goals in the process and conceding just once.
Elsewhere, Real Madrid make a trip to Sporting Huelva on Saturday at the Nuevo Colombino after their heavy 4-0 defeat to Barcelona just before the international break.
The Madrid side look to bounce back and put their campaign on track as they aim to end Barcelona’s dominance although they are eight points behind the log leaders.
The visitors hope that their forwards led by Esther González and Nahikari García Pérez will be at their best complimented by evergreen midfielders Caroline Weir, Maite Oroz and Teresa Abelleira.
On the other hand, Huelva are praying for a repeat of their 3-1 win over Madrid at the same venue.
The sides have met six times with Real Madrid winning four, losing one and drawing one which makes the visitors favourites to win this fixture.
Surprise package Madrid CFF welcome Villarreal at the Estadio Fernando Torres on Saturday afternoon.
The Madrid side have done well beyond expectations so far after losing their top forward Geyse to Barcelona and are second on the standings just five points behind leaders Barcelona.
They hope that their new found goal scorer Racheal Kundananji will continue with her scoring exploits as she has scored seven goals in eight matches.
On the other hand, Villarreal face the possibility of relegation if results keep eluding them.
The teams have met twice with each winning once. Villarreal won this fixture last season and hope to make it two wins in a row at this venue.
Third-placed Atlético Madrid make a trip to Levante Las Planas at the Camp Municipal Les Planes on Sunday afternoon.
A win for the visitors will take them to second position on condition Madrid CFF fail to collect maximum points on Saturday.
The Madrid side have been in leaps and bounds and have dropped just four points in their last five matches whilst Las Planas have collected just four points in their last five matches.
Atlético will be hoping that forward Ludmila is in good form to add onto her current seven goals as she eyes the golden boot prize whilst the hosts will be hoping that experienced forward Mari Paz will be at her best.
The sides have met four times with Atlético winning all the four matches.
UDG Tenerife will be looking forward to collecting maximum points as they travel to face Alhama CF ElPozo at the Campo de Fútbol José María Soriano Muñoz on Saturday afternoon.
Tenerife have been struggling this season and this fixture is one in which they really have to collect points in order to bring their campaign on track.
Alhama, on the other hand, have not collected a single point this season and hope to do so this weekend as they face a fellow struggling side.
History is beckoning as each side is looking forward to winning their first match in their first ever meeting.
On paper the visitors look stronger with forward Jasina Blom and midfielder Pisco who have seen all but results not come their way.
Valencia host Levante on Saturday evening at the Mestalla.
Levante have lost just once in this campaign though they dropped more points from their two draws and hope to collect maximum points to stay in touch with the leading pack whilst Valencia have done well so far collecting 12 points which will prove vital as the season progresses.
Levante have forwards Alba Redondo and Nataša Andonova to look up to for goals whilst the hosts will be hoping that forwards Fiamma Iannuzzi, Macarena Portales Nieto and midfielder Anna Torrodà are at their best.
The teams have met 24 times with Levante winning 13, losing six and drawing five, giving them a better winning probability.
Athletic Club host Real Sociedad at the Lezama Facilities on Saturday night.
The hosts have been performing below par this season and are looking forward to their meeting with Sociedad to make it three wins in a row and boost their campaign whilst the visitors have not hit the ground running this season and will be looking to find a way to establish themselves among the leading sides.
The teams have met 28 times with Athletic Club winning 19, losing five and drawing four, giving them an upper hand although Sociedad will want to build on their dominance in the last two seasons where they have won three of their four meetings.
The El Gran Derbi is loading with Betis hosting rivals Sevilla at the Ciudad Deportiva Luis del Sol on Sunday evening.
The visitors will be looking to make it two wins in a row and move up the standings with their hopes pinned on midfielders Toni Payne and Amanda Sampedro to continue providing vital assists whilst the hosts will be hoping midfielders Grace Asantewaa and Ángela Sosa are in their best form to thwart any attacks from Sevilla.
Betis have done well in previous derbies and hope to continue dominating this fixture whilst Sevilla have been the better side in the last two seasons winning two of their four meetings and drawing the other two.
The teams have met eight times all in all with Betis winning three, losing two and drawing three.
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Fixtures (Saturday): Alhama CF ElPozo vs UDG Tenerife (12:00); Madrid CFF vs Villarreal (12:00); Sporting Huelva vs Real Madrid (16:00); Valencia vs Levante (18:15); Athletic Club vs Real Sociedad (20:00)
All times are Central European Time (CET)